Welcome!
The Molecular Biophysics Core will fill the need to consolidate equipment widely used by the biophysics and biochemistry community. This will facilitate user access, training, instrument maintenance and knowledge dissemination. The core will dramatically reduce or eliminate the need for resources typically expended by host labs for equipment maintenance and user training. It will also provide collaborative project design, development, and implementation for internal and external academic as well as non-academic users.
The core provides a access to a broad range of well maintained equipment and services:
For detailed description and location please follow the "Schedule Equipment" Tab
Radda Rusinova, PhD | Core Manager, Assistant Professor of Research in Physiology and Biophysics
| Hours | Location |
|
Monday - Friday 9am - 5pm |
Room A151/A153/A155 1300 York Ave New York, NY 10065 |
https://weillcornell.az1.qualtrics.com/jfe/form/SV_8Gh79yCXkgTgmHQ
► Ultrasonic Homogenizer
► Osmometer solution testing
► Tabletop Centrifuge
► Expression Vector Design
► Label Free MST
► Lipid Bilayer Properties
► Lipid Vesicle Preparation
► Miscellaneous Supplies/Consumables
| Name | Role | Phone | Location | |
|---|---|---|---|---|
| Radda Rusinova |
Manager
|
212-746-9416
|
rar2021@med.cornell.edu
|
Weill Cornell Medicine 1300 York Ave, Room D501 New York, New York 10065
|
| Service list |
| ► Accessory Instrument (6) | |||
| Name | Description | Price | |
|---|---|---|---|
| Centrifuge Swing Bucket |
|
External
$58.35
month
WCM Internal $50.00 month Corporate $100.00 month |
|
| NanoDrop | Inquire | ||
| pH Meter | Inquire | ||
| Biologics Sonicator |
|
Inquire | |
| Centrifuge Eppendorf |
|
External
$58.35
month
WCM Internal $50.00 month Corporate $100.00 each |
|
| Solution testing |
|
Inquire | |
| ► Cell Culture (1) | |||
| Name | Description | Price | |
| Tissue culture hood |
WCM Internal
$10.00
quarterly
|
||
| ► Experiment Design (1) | |||
| Name | Description | Price | |
| Protocol Design and Toubleshooting |
External
$933.60
each
WCM Internal $800.00 each Corporate $1,600.00 each |
||
| ► Expression Vector Design (1) | |||
| Name | Description | Price | |
| Expression Vector Design | Inquire | ||
| ► Label Free MST (1) | |||
| Name | Description | Price | |
| Label Free MST: NYSBC services | Inquire | ||
| ► Lipid Bilayer Properties (1) | |||
| Name | Description | Price | |
| Determination of Changes in Lipid Bilayer Properties |
Changes in lipid bilayer properties that may occur by varying the lipid composition, and in the presence of molecules that partition to the lipid bilayer may have significant consequences on membrane protein function and therefore cell signaling. Using gramicidin as a probe we can measure changes in bilayer properties by the molecule or lipid composition in question providing key insight into its role in promiscuous and off-target changes in function. The fluorescence-based assay is a fast and robust tool to screen multiple conditions. For detailed description of the method see: Ingolfsson and Andersen. ASSAY and Drug Development Technologies, 2010. DOI: 10.1089/adt.2009.0250 Thasin A. PeyearOlaf S. Andersen; Screening for bilayer-active and likely cytotoxic molecules reveals bilayer-mediated regulation of cell function. J Gen Physiol 3 April 2023; 155 (4): e202213247. doi: https://doi.org/10.1085/jgp.202213247 |
Inquire | |
| ► Lipid Vesicle Preparation (1) | |||
| Name | Description | Price | |
| Lipid Vesicle Preparation |
|
Inquire | |
| ► Supplies (8) | |||
| Name | Description | Price | |
| Cuvette | Inquire | ||
| Disposable Borosilicate Glass Tubes |
Fisher 10ml https://www.fishersci.com/shop/products/fisherbrand-disposable-borosilicate-glass-tubes-plain-end-10/1496127 |
External
$0.17
each
WCM Internal $0.17 each WCM Internal - Special $0.17 each Corporate $0.17 each |
|
| Filter | Inquire | ||
| Monolith Capillaries | Inquire | ||
| Monolith Label Free Capillaries | Inquire | ||
| Monolith Premium Capillaries | Inquire | ||
| Slides for Refeyn | Inquire | ||
| Tycho NT.6 capillaries | Inquire | ||
| Name | Price | |
|---|---|---|
| AKTA Pure | ||
| DLS/ELS Anton Paar | ||
| Stopped flow spectrofluorometer SX20 Single Mixing | ||
| Stopped flow spectrofluorometer SX20 Sequential/Double Mixing | ||
| TA Instruments Nano ITC | ||
| TA Instruments Standard Volume ITC | ||
| TA Instruments Affinity Auto ITC | ||
| TA Instruments DSC | ||
| Horiba/PTI QuantaMaster 40 | ||
| ThermoScientific Genesys-180 Spectrophotometer | ||
| Microscale Thermophoresis NanoTemperTech Monolith NT.115 | ||
| NanoTemperTech Tycho NT.6 | ||
| Refeyn Mass Photometer | ||
| Nanion SURFE2R | ||
| Shimadzu Fluorescence-Detection Size-Exclusion Chromatography | ||
| Tissue Culture CO2 Incubator Shaker | View calendar | |
| Bacterial shaker | ||
| Sf9 Shaker | ||
