News
- Note: due to the pandemic, for sample drop-off, please schedule a time in advance with core staff to ensure that someone will be in the lab.
- Dec 2020 New services available: folate metabolite profiling
- Jan 2020 New services available: Untargeted metabolite profiling.
- Oct 2019 New services available for lipids, fatty acids, bile acids, acyl-carnitines and short chain acyl-CoAs.
- More News ...
Services
Established in 2016, the Weill Cornell Medicine (WCM) Meyer Cancer Center Proteomics and Metabolomics Core Facility offers mass spectrometry-based analysis of proteins, peptides, metabolites and other biochemical molecules, to Weill Cornell Medicine users as well as external users from academic institutions and commercial enterprises.
- Proteomics
- Protein Identification
- protein in gel / in solution
- Protein Quantitation
- Popular applications: protein expression profiling; protein interactions (IP); proximity-based labeling for interactome mapping (APEX); Thermo Proteome Profiling (TPP)/Cellular Thermal Shift Assay (CETSA); etc.
- Methods include: SILAC, TMT, Label-free, spiked standards, etc.
- Post-Translational Modification (PTM)
- Popular applications: protein phosphorylation profiling; PTM characterization of purified protein; histone modifications; etc.
- PTMs include: Phosphorylation, ubiquitination, acetylation, N/C-term processing, etc.
- Metabolomics
- Targeted profiling of polar metabolites (Targeted detection of metabolites in a predefined panel, which includes many central metabolites such as glycolysis/TCA intermediates and amino acids. See the list HERE. See a Sample report. )
- Stable isotope tracing / flux for polar metabolites (e.g. C13 glucose labeling. See a Sample report. )
- Type 1: Tracing of selected metabolites (Please select metabolites from the LIST to avoid ambiguity.)
- Type 2: Full panel tracing (Exhaustive tracing of all detected metabolites. No need to know beforehand if a particular metabolite is labeled or not. Note: minimum 6 samples)
- Untargeted metabolite profiling (See details HERE.)
- Lipid profiling (See the list HERE.)
- Free fatty acid profiling (See the list HERE.)
- Bile acids (See the list HERE.)
- Acylcarnitine profiling (See the list HERE.)
- Short chain Acyl-CoAs (See the list HERE.)
- Folate metabolites (See the list HERE.)
- Thyroid hormones triiodothyronine/thyroxine (T3/T4) absolute quantitation (100 ul serum is needed)
- Targeted analysis of 7 polyamines (See the list HERE.)
- Accurate MW measurement for drugs/chemicals (mass accuracy: a few ppm)
- New method development
Notes:
- Unless otherwise noted, quantitation in all assays is relative quantitation, not absolute.
- Turnaround time is normally 5-10 business days, except for global protein/PTM profiling (~4 weeks).
Sample Preparation Protocols
Fees
- Click HERE to see pricing
- Note: service rates are adjusted annually to reflect changes in running cost
Service Request
Note: All service requests are done via the online iLab system. An iLab account is needed for sample submissions.
Instrumentation

Orbitrap Fusion Lumos

Orbitrap Q Exactive / Vanquish UPLC
- Easy-nLC 1200 UPLC
- Agilent 1260
Links and Resources
- recommended free online tool for metabolomics data analysis
Contact Us
Director
Guoan Zhang PhD
guz2004@med.cornell.edu
Phone (646) 962-6222
Staff
Dr. Mengmeng Zhu - mez2005@med.cornell.edu
Dr. Xiaoyuan Yang - xiy4003@med.cornell.edu
Phone (646) 962-9739
Sample Drop-off / Shipping Address
413 East 69th Street, BRB 1552 (Zhang lab)
New York, NY 10021
Lab phone: 646-962-9739
(For sample drop off, please drop off to Lab 1552 of Belfer building. Call 646-962-9739 to get into the glass door when arriving at 15th floor.)
Note: due to the pandemic, for all sample drop-off, please schedule a time in advance with core staff to ensure that some one will be in the lab.