WCM Proteomics and Metabolomics Core Facility

News

2017-05 We release new services for polar metabolite profiling.

2017-01-14 Billing for Tri-Institutional Therapeutics Discovery Institute  (TDI) users through iLAB has been streamlined. Journal voucher processing will not be needed in the future.

 

Overview of Services

Established in 2016, the Weill Cornell Medicine (WCM) Proteomics and Metabolomics Core Facility provides mass spectrometry based analysis of proteins, peptides, metabolites and other biochemical molecules.

The resources and services of the core facility are open to all investigators at Weill Cornell Medicine, Cornell University and Cornell-affiliated institutions.  The facility also provides services to external investigators at both academic institutions and commercial enterprises.

 

Services

  • Proteomics
    • Protein Identification: ID of proteins from SDS-PAGE and of proteins in-solution. 
    • Protein Quantitation: Label-free (intensity based / spectral counting); stable isotope labeling by amino acids in cell culture (SILAC); tandem mass tags (TMT); spiked standards. 
    • Post-Translational Modification Analysis: Phosphorylation; ubiquitination; acetylation; N-term / C-term processing; other PTMs. 
    • Data Analysis: Database searching; statistical analysis for quantitation.
  • Metabolomics
    • targeted profiling of polar metabolites. See the list HERE. 
    • Stable isotope tracing
    • Absolute quantitation
    • New method development

Note: High resolution instruments are used in all mass spec services.

 

Instrumentation

  • Orbitrap Fusion Lumos 
  • Orbitrap Q Exactive 
  • Vanquish UPLC
  • Easy-nLC 1200 UPLC 
  • Easy-nLC 1000 UPLC 

Publications

list of publications on Pubmed

Links and Resources

Contact us

Director

Guoan Zhang PhD
guz2004@med.cornell.edu
(646) 962-6222

 

Core Staff

Zhe Cheng - zhc2010@med.cornell.edu
Taojunfeng Su - tas2033@med.cornell.edu
Yimeng (Lizzy) Zhao - yiz2016@med.cornell.edu
(646) 962-9739

Location/Shipping Address

413 East 69th Street, BRB 1552
New York, NY 10021
Lab phone: 646-962-9739