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Epigenomics Core

Getting Started


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The Epigenomics Core at Weill Cornell Medicine provides scientific support for researchers working on epigenetic and epigenomics. 


Epigenomics is the study of heritable genome wide changes in phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence. The proper control and ordering of gene expression is associated and partially controlled through DNA sequence-independent biochemical events collectively known as epigenetic gene regulation. These include but are not limited to DNA methylation and a wide range of histone modifications. Similar to the genetic information found within the sequence of DNA, epigenetic information can be inherited across generations, transmitted by mother to daughter cells, and is required for life. Epigenetic regulation is known to affect gene expression, and recent research shows that aberrant DNA methylation patterning may play a role in the manifestation, progression and therapy of several diseases. A deeper understanding of the epigenetic changes associated with disease can lead to improved diagnostics and can ultimately be applied towards development of therapy.


Our services include scientific consultation, experimental implementation, data processing, bioinformatics analysis and data storage.  Our goal is to be at the developing edge of new methodologies, both experimentally and computationally.


We require that core clients acknowledge the Epigenomics Core of Weill Cornell Medicine in publications and presentions enabled by Epigenomics core resources. 

For information regarding our services, please visit our website:






  Ari Melnick Faculty Advisor WCMC, 1300 York Avenue, C-620, New York, NY 10021 212-746-7643
  Alicia Alonso Facility Director WCMC, 1300 York Avenue, A-427, New York, NY 10065 212-746-4406


 WCM, 1300 York Avenue, A-427, New York, NY 10065  

Links and Resources


    1. Epigenomics home page -
    2. Melnick Lab home page - 


Name Role Phone Email Location
Alicia Alonso, PhD
Core Director

Yushan Li
Core Manager
Weill Cornell Medicine, Box 288, 1300 York Avenue New York, NY 10065