The role of the Mouse Genetics Core Facility (MGCF) is to facilitate the use of mouse molecular genetics for investigators at MSKCC and neighboring institutions, including WCMC, for in vivo studies of gene functions. The expertise of MGCF covers 3 broad technical areas for the generation and utilization of genetically engineered mice (GEM), namely molecular and cell biology, embryo manipulation, and reproductive biology. As an integral role of the MGCF, staff members regularly engage with investigators in consultation, discussion, and training in the design and production of GEM models, ES cell manipulation, and GEM breeding and genetics. In addition, MGCF continues to pursue and implement new technical developments that will expedite GEM generation. Much of MGCF's recent effort has been devoted to technical advancements in genome editing using CRISPR/Cas9 system and in ES cell approaches to generate mice with complex genetic modifications, which will contribute to the productivity of WCM investigators.
Mon - Fri, 9am - 5pm ET
Mouse Genetics Core Facility Website
http://onemsk/ski/MouseGenCF/Pages/MGCFHome.aspx
Jax Website
Molecular and Cell Biology
Embryo Manipulation
Reproductive Biology